LPKF Laser & Electronics: Federal Ministry of Education and Research promotes joint project “B-cell immune”

Garbsen, October 24, 2022 – Since September 2022, inno-train Diagnostik GmbH, Medizinische Hochschule Hannover (MHH), the Fraunhofer-Institut für Lasertechnik ILT and LPKF Laser & Electronics AG have pooled their expertise in a joint research project on infection prevention and treatment epidemic. The partners have now received financial support from the German Federal Ministry of Education and Research (BMBF) for their project, which promotes the development of a new analytical method to determine the individual immune response to SARS-CoV- 2. The financial support enables the project “High-throughput analysis of virus-specific memory B-cells to determine individual immune responses”, or in short “B-cell-immune”, and is part of the program “Prevention and treatment of epidemic infections with innovative medical technologies”.

The past pandemic shows how important rapid responses to new viruses, virus variants and unknown diseases are. Current technologies are quickly reaching their limits, whether due to the large quantity of reagents required or the limited throughput of laboratory equipment.

As part of the “B-Cell-Immune” project, the partners are working together to develop a high-throughput method for the harvesting and selective sequencing of virus-specific memory B cells and a diagnostic kit with PCR detection. Memory B cells represent the immune system‘s memory of previous infections or vaccinations. The goal is to greatly simplify the determination of immune status in large populations. The high-throughput method developed can, for example, significantly reduce costs for the healthcare system in the event of a new pandemic and play an important role in political decisions.

The single-cell ARRALYZE platform developed by LPKF and the glass chips produced using LIDE technology, play a central role in the project: by miniaturizing and automating the analysis of individual cells and biological processes, the technology brings significant contribution to the development of a high throughput platform to analyze the immune status of large populations.

DNA chips are filled with cells, substrates or media. To this end, the Fraunhofer ILT will work with LPKF to further develop the “laser-induced direct transfer” (LIFT) process. This highly precise, non-contact printing process is used to fill small microscopic wells and to remove cells. Pipette tips become unnecessary in this context and the sample volume required for diagnosis can be reduced.

Founded in 1998, inno-train Diagnostik GmbH is an international supplier of a full range of products in the field of human leukocyte antigens (HLA) and the world’s leading supplier of self-produced PCR genotyping tests for blood group determination. inno-train uses this know-how to develop a PCR test based on new biomarkers that can be used to determine the immune status against specific viruses.

Under the direction of Prof. Dr. Blasczyk, a team at MHH supports the core part of biological research with the aim of analyzing and characterizing virus-specific B cell biomarkers. The MHH has extensive experience as a leading transplant center in Europe and contributes to the project with significant resources from the blood donation service. “This method takes antibody-based therapy and diagnostics to a whole new level,” emphasizes Ms. Dr. Bade-Döding, project manager at the MHH.

About LPKF

LPKF Laser & Electronics AG is one of the leading providers of laser solutions for the technology industry. LPKF’s laser systems are crucial for the production of printed circuit boards, microchips, automotive parts, solar modules and many other components. Founded in 1976, the company is headquartered in Garbsen near Hanover, Germany, and is active worldwide through subsidiaries and representatives. The shares of LPKF Laser & Electronics AG are traded on the Deutsche Börse Prime Standard (ISIN 0006450000).

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